Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC047
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-18 13:49
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/4 New patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 2 individuals with a value less than 0.51 were subsequently diagnosed with PD. That is, 4.76% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.51 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 40, 'TN': 30, 'TP': 2, 'FP': 0}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 20, 'TN': 17, 'TP': 22, 'FP': 13}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 33, 'TN': 28, 'TP': 9, 'FP': 2}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 7, 'TN': 5, 'TP': 35, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 20.68
timePerCircleCoV 0.32562
timePerCircleSlope -0.0769943
meanError 1.34478
tremorFreq 5.85938
tremorRelPower 28.18
tremorGyroAmpMean 0.0137014
tremorGyroAmpSlope 0.00112516
tremorGyroAmpCoV 0.480773
tremorCoordAmpMean 0.0307931
tremorCoordAmpSlope -0.000985007
tremorCoordAmpCoV 0.371324
tremorAccAmpMean 0.0486571
tremorAccAmpSlope -0.00046314
tremorAccAmpCoV 0.148276
tremorPcRelVar 0.713922
tremorPcX -0.238724
tremorPcY 0.971088

Circle Segment 1

Duration 18.36 s, Accuracy Estimate 1.223 (lower is better)

Circle Segment 2

Duration 31.8 s, Accuracy Estimate 1.941 (lower is better)

Circle Segment 3

Duration 30.96 s, Accuracy Estimate 1.599 (lower is better)

Circle Segment 4

Duration 27.2 s, Accuracy Estimate 1.386 (lower is better)

Circle Segment 5

Duration 17.6 s, Accuracy Estimate 0.875 (lower is better)

Circle Segment 6

Duration 17.84 s, Accuracy Estimate 1.223 (lower is better)

Circle Segment 7

Duration 17.92 s, Accuracy Estimate 1.384 (lower is better)

Circle Segment 8

Duration 16.6 s, Accuracy Estimate 1.057 (lower is better)

Circle Segment 9

Duration 16.08 s, Accuracy Estimate 0.806 (lower is better)

Circle Segment 10

Duration 12.44 s, Accuracy Estimate 1.955 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 41.7067
timePerSpiralCoV 0.155915
timePerSpiralSlope -0.0590245
meanError 1.63381
tremorFreq 5.85938
tremorRelPower 37.9603
tremorGyroAmpMean 0.0208697
tremorGyroAmpSlope 0.00179499
tremorGyroAmpCoV 0.669656
tremorCoordAmpMean 0.0406553
tremorCoordAmpSlope 0.00222607
tremorCoordAmpCoV 1.04807
tremorAccAmpMean 0.0508484
tremorAccAmpSlope -4.50209e-05
tremorAccAmpCoV 0.208692
tremorPcRelVar 0.81483
tremorPcX 0.310915
tremorPcY -0.950438

Spiral Segment 1

Duration 52.64 s, Accuracy Estimate 1.874 (lower is better)

Spiral Segment 2

Duration 37.08 s, Accuracy Estimate 1.595 (lower is better)

Spiral Segment 3

Duration 43.92 s, Accuracy Estimate 1.505 (lower is better)

Spiral Segment 4

Duration 42.6 s, Accuracy Estimate 1.788 (lower is better)

Spiral Segment 5

Duration 40.2 s, Accuracy Estimate 1.622 (lower is better)

Spiral Segment 6

Duration 33.8 s, Accuracy Estimate 1.418 (lower is better)

Elel

eDurationMean 0.775263
eDurationStd 0.189425
eDurationStdnorm 0.244337
eDurationMedian 0.73
eDurationQuartdelta 0.29375
eDurationQuartdeltanorm 0.402397
eDurationKurt 1.79658
eDurationTrenddiff -0.215
eDurationTrendratio 0.758427
eWidthMean 5.36353
eWidthStd 1.93326
eWidthStdnorm 0.360446
eWidthMedian 5.031
eWidthQuartdelta 2.42775
eWidthQuartdeltanorm 0.482558
eWidthKurt 3.19693
eWidthTrenddiff 0.936
eWidthTrendratio 1.20513
eHeightMean 6.65668
eHeightStd 1.93154
eHeightStdnorm 0.290166
eHeightMedian 6.903
eHeightQuartdelta 3.2175
eHeightQuartdeltanorm 0.466102
eHeightKurt 2.09772
eHeightTrenddiff 0.117
eHeightTrendratio 1.01695
eAspectMean 0.841717
eAspectStd 0.295254
eAspectStdnorm 0.350776
eAspectMedian 0.767857
eAspectQuartdelta 0.403971
eAspectQuartdeltanorm 0.526102
eAspectKurt 2.11636
eAspectTrenddiff 0.0918008
eAspectTrendratio 1.13579
eSlantMean -0.390999
eSlantStd 0.373343
eSlantStdnorm -0.954843
eSlantMedian -0.325
eSlantQuartdelta 0.607008
eSlantQuartdeltanorm -1.86772
eSlantKurt 2.08094
eSlantTrenddiff 0.385611
eRtopMean 0.60474
eRtopStd 0.212039
eRtopStdnorm 0.350629
eRtopMedian 0.590909
eRtopQuartdelta 0.345426
eRtopQuartdeltanorm 0.584566
eRtopKurt 1.97806
eRtopTrenddiff 0.234694
eRbotMean 1.11358
eRbotStd 0.506129
eRbotStdnorm 0.454505
eRbotMedian 1.08333
eRbotQuartdelta 0.641924
eRbotQuartdeltanorm 0.592545
eRbotKurt 3.01673
eRbotTrenddiff -0.362245
eRrightMean 0.61991
eRrightStd 0.242801
eRrightStdnorm 0.391671
eRrightMedian 0.714286
eRrightQuartdelta 0.385152
eRrightQuartdeltanorm 0.539213
eRrightKurt 2.49506
eRrightTrenddiff 0.0841459
eRleftMean 0.522762
eRleftStd 0.147131
eRleftStdnorm 0.28145
eRleftMedian 0.535211
eRleftQuartdelta 0.246972
eRleftQuartdeltanorm 0.461448
eRleftKurt 2.23545
eRleftTrenddiff -0.202381
lDurationMean 1.29
lDurationStd 0.499698
lDurationStdnorm 0.387363
lDurationMedian 1.145
lDurationQuartdelta 0.625
lDurationQuartdeltanorm 0.545852
lDurationKurt 3.25654
lDurationTrenddiff -0.4
lDurationTrendratio 0.719298
lWidthMean 7.281
lWidthStd 2.01927
lWidthStdnorm 0.277335
lWidthMedian 7.3125
lWidthQuartdelta 3.861
lWidthQuartdeltanorm 0.528
lWidthKurt 2.03087
lWidthTrenddiff 1.287
lWidthTrendratio 1.19643
lHeightMean 13.896
lHeightStd 2.87378
lHeightStdnorm 0.206807
lHeightMedian 14.742
lHeightQuartdelta 3.744
lHeightQuartdeltanorm 0.253968
lHeightKurt 2.95975
lHeightTrenddiff -1.17
lHeightTrendratio 0.921875
lAspectMean 0.547819
lAspectStd 0.183903
lAspectStdnorm 0.335701
lAspectMedian 0.545959
lAspectQuartdelta 0.223128
lAspectQuartdeltanorm 0.40869
lAspectKurt 2.18431
lAspectTrenddiff -0.0490006
lAspectTrendratio 0.917272
lSlantMean -0.0803982
lSlantStd 0.261783
lSlantStdnorm -3.25607
lSlantMedian -0.103215
lSlantQuartdelta 0.367077
lSlantQuartdeltanorm -3.55644
lSlantKurt 2.08641
lSlantTrenddiff 0.31932
lRtopMean 0.766139
lRtopStd 0.18149
lRtopStdnorm 0.236889
lRtopMedian 0.769041
lRtopQuartdelta 0.31352
lRtopQuartdeltanorm 0.407676
lRtopKurt 1.87684
lRtopTrenddiff 0.284347
lRbotMean 0.964863
lRbotStd 0.427444
lRbotStdnorm 0.44301
lRbotMedian 0.995883
lRbotQuartdelta 0.64951
lRbotQuartdeltanorm 0.652195
lRbotKurt 3.65784
lRbotTrenddiff -0.419182
lRrightMean 0.797219
lRrightStd 0.204024
lRrightStdnorm 0.25592
lRrightMedian 0.857853
lRrightQuartdelta 0.2275
lRrightQuartdeltanorm 0.265197
lRrightKurt 5.63818
lRrightTrenddiff 0.18446
lRleftMean 0.402956
lRleftStd 0.147217
lRleftStdnorm 0.365341
lRleftMedian 0.378132
lRleftQuartdelta 0.207039
lRleftQuartdeltanorm 0.547533
lRleftKurt 3.60835
lRleftTrenddiff -0.0599702

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

FITTS Short Modified

meanTouchScore 0.891954
sumTouchScores 17.8391
meanMovementTime 0.894737
numTouches 20
undershootPercentage 0
overshootPercentage 45

FITTS Long Modified

meanTouchScore 0.896426
sumTouchScores 14.3428
meanMovementTime 1.17733
numTouches 16
undershootPercentage 0
overshootPercentage 6.25

ZigZag

numZigzags 4
timePerZigzagMean 34.8
timePerZigzagCoV 0.0753787
timePerZigzagSlope -0.0177011
meanError 3.26651
tremorFreq 5.27344
tremorRelPower 43.9148
tremorGyroAmpMean 0.0257026
tremorGyroAmpSlope 0.00302593
tremorGyroAmpCoV 0.437768
tremorCoordAmpMean 0.0581025
tremorCoordAmpSlope 0.00191801
tremorCoordAmpCoV 0.310924
tremorAccAmpMean 0.0465947
tremorAccAmpSlope 0.00240078
tremorAccAmpCoV 0.362607
tremorPcRelVar 0.790649
tremorPcX -0.416565
tremorPcY 0.909106

ZigZag Segment 1

Duration 34.96 s, Accuracy Estimate 3.282 (lower is better)

ZigZag Segment 2

Duration 37.8 s, Accuracy Estimate 3.264 (lower is better)

ZigZag Segment 3

Duration 31.4 s, Accuracy Estimate 2.916 (lower is better)

ZigZag Segment 4

Duration 35.04 s, Accuracy Estimate 3.604 (lower is better)

ZigZag Offset

numZigzags 4
timePerZigzagMean 27.72
timePerZigzagCoV 0.0755615
timePerZigzagSlope -0.0464646
zigzagHeightMean 63.7612
zigzagHeightCoV 0.0223162
zigzagHeightSlope -0.01507
meanError 0.0659885
tremorFreq 5.85938
tremorRelPower 34.9562
tremorGyroAmpMean 0.0295822
tremorGyroAmpSlope 0.00203475
tremorGyroAmpCoV 0.400183
tremorCoordAmpMean 0.0600477
tremorCoordAmpSlope 0.00241178
tremorCoordAmpCoV 0.399933
tremorAccAmpMean 0.0672105
tremorAccAmpSlope 0.00195944
tremorAccAmpCoV 0.257498
tremorPcRelVar 0.801997
tremorPcX 0.29265
tremorPcY -0.95622

ZigZag Offset Segment 1

Duration 29.44 s, Accuracy Estimate 0.094 (lower is better)

ZigZag Offset Segment 2

Duration 27.76 s, Accuracy Estimate 0.095 (lower is better)

ZigZag Offset Segment 3

Duration 28.92 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 4

Duration 24.76 s, Accuracy Estimate 0.046 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.54}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.51}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.9340480233510429}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8901463187939542}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.8015260902824735}